The effect of topical applied curcumin on wound healing in nasal septal perforation model created in rabbits.

Çakan D., Aydın S., Demir M. G., Başak K., Çakıl T.

20.Rhinocamp, Muğla, Turkey, 9 - 12 May 2018, pp.144

  • Publication Type: Conference Paper / Full Text
  • City: Muğla
  • Country: Turkey
  • Page Numbers: pp.144
  • Istanbul University Affiliated: Yes


20th Rhinocamp Meeting Proceedings

9-12 May, 2018 Marmaris • TURKEY



The Effect of Topical Applied Curcumin on Wound Healing in Nasal Septal Perforation

Model Created in Rabbits

Doğan Çakan1

, Sedat Aydın1

, Mehmet Gökhan Demir2

, Kayhan Başak3

, Tolga Çakıl1


Kartal Dr.Lutfi Kirdar Education and Research Hospital, ENT Department,Istanbul 2

Etimesgut State Hospital, ENT Department, Ankara 3

Kartal Dr.Lutfi Kirdar Education and Research Hospital, Pathology Department, Istanbul

Aim: In this experimental study, we investigated the effect of intranasal topical curcumin on wound healing in nasal septum

mucosa in a model of nasal septal perforation in rabbits.

Materials and method: A male New Zealand rabbit with no evidence of nasal septal pathology and infection with 14 anterior

rhinoscopic examinations was included in the study. Grouped into 7 subjects in each group. Circular perforation behind the

nasal columella about 5 mm posterior and 5 mm in diameter was created on the nasal septum mucosa in each experiment.

Curcumin was applied to the study group and control group was also given saline. Intranasal administration was performed as

topical agent once daily for 10 days. At the end of the 10th day, a 10x10 mm through-cut nasal septum excision was made to

include the perforated area. Histopathological examination of specimens were compared taking into account such parameters as

epithelial regeneration and degeneration in groups, fibroblast and collagen presence, capillary vessel density, acute and chronic

inflammatory cell presence, eosinophils amount, the amount of granulation tissue, giant cell presence, cartilage degeneration and

regeneration, the macroscopic closure rate of the perforation.

Results: there was a statistically significant difference between groups according to epithelial and cartilage regeneration and the

amount of collagen and granulation tissue. It was significantly higher in the curcumin group than in the control group. (p<0,05).

No statistically significant difference was found in comparison of other parameters. (p>0.05).

Conclusion: Our findings support that curcumin has an accelerating effect on wound healing in the nasal septal mucosa. For this

reason, we may think that curcumin may be beneficial in preventing the development of septal perforation.

Key words: Curcumin, nasal septal perforation, nasal septum, experimental study, wound healing, topical.