Hyperhomocysteinemia in inflammatory bowel disease patients without past intestinal resections - Correlations with cobalamin, pyridoxine, folate concentrations, acute phase reactants, disease activity, and prior thromboembolic complications

Erzin Y., Uzun H., Celik A. F., Aydin S., Dirican A., Uzunismail H.

JOURNAL OF CLINICAL GASTROENTEROLOGY, cilt.42, sa.5, ss.481-486, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1097/mcg.0b013e318046eab0
  • Dergi Adı: JOURNAL OF CLINICAL GASTROENTEROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.481-486
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Homocysteine is a sulfur-containing amino acid formed during the demethylation of methionine and high levels of this amino acid is a known risk factor for both arterial and also venous thromboembolic complications. Deficiencies of cobalamin, folate, and pyridoxine may predispose subjects to hyperhomocysteinemia, a common phenomenon in inflammatory bowel disease (IBD) patients. The aim of this study was to identify the prevalence, risk factors of hyperhomocysteinemia and its correlation with prior thromboembolic events in an IBD cohort without past intestinal resections.