Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behcet's disease

Vural, BURÇAK; Sehitoglu, Elcin; Cavus, Filiz; Yalcinkaya, Nazh; Haytural, Hazal; Kucukerden, Melike; Ulusoy, CANAN; Ugurel, Elif; Turan, Selin; Bulut, Leyla; TURKOGLU, Recai; Shugaiv, Erkingul; Kurtuncu, MURAT; Atakan, Sukru; Gure, Ali; Gul, AHMET; Eraksoy, Mefkure; Akman-Demir, Gulsen; Tuzun, ERDEM

doi:10.1016/j.jneuroim.2013.08.007

Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behcet's disease

Vural B., Sehitoglu E., Cavus F., Yalcinkaya N., Haytural H., Kucukerden M., ...Daha Fazla

JOURNAL OF NEUROIMMUNOLOGY, sa.1-2, ss.139-144, 2013 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Basım Tarihi: 2013
Doi Numarası: 10.1016/j.jneuroim.2013.08.007
Dergi Adı: JOURNAL OF NEUROIMMUNOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.139-144
Anahtar Kelimeler: Behcet's disease, Neuro-Behcet's disease, Anti-neuronal antibody, Mitochondrial carrier homolog 1, Antibody, Autoimmunity, CLINICAL-SIGNIFICANCE, DIAGNOSTIC-CRITERIA, PATHERGY REACTION, SERUM-LEVELS, PROTEIN
İstanbul Üniversitesi Adresli: Evet

Özet

Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation. (C) 2013 Elsevier B.V. All rights reserved.