INFLUENCE OF ACUTE EXPOSURE TO HEAT ON THE BLOOD-BRAIN-BARRIER PERMEABILITY DURING ACUTE HYPERTENSION
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, cilt.52, sa.2, ss.375-378, 1995 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 52 Sayı: 2
- Basım Tarihi: 1995
- Doi Numarası: 10.1016/0091-3057(95)00121-c
- Dergi Adı: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.375-378
- İstanbul Üniversitesi Adresli: Hayır
Özet
In mild hyperthermic rats with acute hypertension induced by intravenous injection of adrenaline, changes in blood-brain barrier permeability to macromolecules were investigated using Evans blue as indicator. Evans blue albumin extravasation was determined macroscopically, and a quantitative estimation with spectrophotometer using homogenized brain to release the dye was also performed to evaluate the macroscopic findings. Four groups of rats were studied: group I: control normothermia; group II: acute exposure to heat; group III: normothermia + acute hypertension; group IV: acute exposure to heat + acute hypertension. The rats were anesthetized with diethyl-ether. Body temperature was increased by elevating ambient temperature in the vented box covered with a 3 mm thick black copper plate. The colonic temperature was increased to 39 +/- 0.5 degrees C. During adrenaline-induced acute hypertension the mean arterial blood pressure increased in both normothermic and mild hyperthermic animals. Mean values for Evans blue dye were found to be 0.20 +/- 0.04 mg% whole brain in normothermic control rats and 0.30 +/- 0.1 mg% in hyperthermic rats (p < 0.05). Mean values for Evans blue dye in the whole brain were found to be 0.63 +/- 0.2 mg% in the normothermic rats and 0.40 +/- 0.2 mg% in the mild hyperthermic rats during adrenaline-induced hypertension (p < 0.05). Our results show that the extravasation of Evans blue albumin was less pronounced in the brains of mild hyperthermic rats compared to normothermic rats after adrenaline-induced acute hypertension.