How to Manage an Unresectable or Recurrent Sialoblastoma

Saribeyoglu E. T., Devecioglu O., Karakas Z., Anak S., Unuvar A., Agaoglu L., ...More

PEDIATRIC BLOOD & CANCER, vol.55, no.2, pp.374-376, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 55 Issue: 2
  • Publication Date: 2010
  • Doi Number: 10.1002/pbc.22464
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.374-376
  • Istanbul University Affiliated: Yes


Only 2-5% of all salivary gland tumors occur in children. Sialoblastoma is an extremely rare salivary gland tumor diagnosed at birth or shortly thereafter with significant variability in histological range and clinical course, so that it may be difficult to predict the most appropriate therapy. In cases where surgical removal is not curative or technically feasible, chemotherapy may be attempted. We report herein a patient with progression of a huge partially resected sialoblastoma who was successfully treated with chemotherapy. Systemic chemotherapy with vincristine, actinomycin D, and cyclophosphamide (VAC) seems to be an effective adjuvant or neoadjuvant treatment option for unresectable or recurrent sialoblastoma. Pediatr Blood Cancer 2010;55:374-376. (C) 2010 Wiley-Liss, Inc.