Involvement of the pineal gland in diurnal cocaine reward in mice

KÜRTÜNCÜ M., Arslan A., Akhisaroglu M., Manev H., Uz T.

EUROPEAN JOURNAL OF PHARMACOLOGY, cilt.489, sa.3, ss.203-205, 2004 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 489 Sayı: 3
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1016/j.ejphar.2004.03.010
  • Dergi Adı: EUROPEAN JOURNAL OF PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.203-205
  • Anahtar Kelimeler: cocaine, conditioned place preference, (mouse), circadian rhythm, pinealectomy, LOCOMOTOR-ACTIVITY, CIRCADIAN GENES, SENSITIZATION, EXPRESSION, RHYTHM, MOUSE
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Contribution of circadian mechanisms to the psychostimulant-induced behaviors has been suggested. The pineal gland is important component of circadian mechanisms. Using pinealectomized mice and sham-operated controls, we tested the contribution of pineal gland to the rewarding effects of cocaine in conditioned place preference test. Experiments were performed both during the day and at night. Controls with intact pineal glands demonstrated significant decrease in cocaine-induced conditioned place preference at night compared to daytime, whereas pinealectomized mice did not show any diurnal differences. Circadian mechanisms regulated by the pineal gland thus appear critically involved in cocaine-induced reward. (C) 2004 Elsevier B.V. All rights reserved.