Autologous anti-SOX2 antibody responses reflect intensity but not frequency of antigen expression in small cell lung cancer


Atakan S., Bayiz H., SAK S., Poyraz A., VURAL B. , Yildirim A. S. , ...More

BMC CLINICAL PATHOLOGY, vol.14, 2014 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2014
  • Doi Number: 10.1186/1472-6890-14-24
  • Journal Name: BMC CLINICAL PATHOLOGY
  • Journal Indexes: Emerging Sources Citation Index, Scopus
  • Keywords: Tumor immunology, Cancer stem cells, Autologous antibody responses, Tumor antigens, Lung cancer, Immunohistochemistry, Autologous antibodies, Cancer stem-cells

Abstract

Background: Anti-SOX2 antibody responses are observed in about 10 to 20% of small cell lung cancer (SCLC) patients. The aim of this study was to determine whether such responses reflect a particular pattern of SOX2 protein expression in the tumor and whether this pattern associates with clinical outcome.