Autologous anti-SOX2 antibody responses reflect intensity but not frequency of antigen expression in small cell lung cancer

Atakan S., Bayiz H., SAK S., Poyraz A., VURAL B., Yildirim A. S., ...Daha Fazla

BMC CLINICAL PATHOLOGY, cilt.14, 2014 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1186/1472-6890-14-24
  • Dergi Adı: BMC CLINICAL PATHOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus
  • Anahtar Kelimeler: Tumor immunology, Cancer stem cells, Autologous antibody responses, Tumor antigens, Lung cancer, Immunohistochemistry, Autologous antibodies, Cancer stem-cells
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Anti-SOX2 antibody responses are observed in about 10 to 20% of small cell lung cancer (SCLC) patients. The aim of this study was to determine whether such responses reflect a particular pattern of SOX2 protein expression in the tumor and whether this pattern associates with clinical outcome.