Autologous anti-SOX2 antibody responses reflect intensity but not frequency of antigen expression in small cell lung cancer


Atakan S., Bayiz H., SAK S., Poyraz A., VURAL B., Yildirim A. S., ...More

BMC CLINICAL PATHOLOGY, vol.14, 2014 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 14
  • Publication Date: 2014
  • Doi Number: 10.1186/1472-6890-14-24
  • Journal Name: BMC CLINICAL PATHOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus
  • Keywords: Tumor immunology, Cancer stem cells, Autologous antibody responses, Tumor antigens, Lung cancer, Immunohistochemistry, Autologous antibodies, Cancer stem-cells
  • Istanbul University Affiliated: Yes

Abstract

Background: Anti-SOX2 antibody responses are observed in about 10 to 20% of small cell lung cancer (SCLC) patients. The aim of this study was to determine whether such responses reflect a particular pattern of SOX2 protein expression in the tumor and whether this pattern associates with clinical outcome.