Reduced Peripheral Blood Mononuclear Cell ROCK1 and ROCK2 Levels in Obstructive Sleep Apnea Syndrome

Aydin S., Ozdemir C., Kucukali C. I., Sokucu S. N., Giris M., Akcan U., ...Daha Fazla

IN VIVO, cilt.32, sa.2, ss.319-325, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.21873/invivo.11240
  • Dergi Adı: IN VIVO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.319-325
  • Anahtar Kelimeler: Obstructive sleep apnea syndrome, rho-associated protein kinase, ROCK, triglycerides, polysomnography, sleep, RHO KINASE INHIBITION, ENDOTHELIAL DYSFUNCTION, HONG-KONG, PREVALENCE, MEN, POPULATION, DISEASE, EPIDEMIOLOGY, DISORDERS, COMMUNITY
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background/Aim: Obstructive sleep apnea syndrome (OSAS) is associated with intermittent episodes of hypoxia, endothelial dysfunction and associated cardiovascular problems. Our aim was to investigate whether OSAS-related hypoxia alters the expression of rhoassociated protein kinase (ROCK), a marker of chronic hypoxia and endothelial dysfunction. Materials and Methods: ROCK1 and ROCK2 levels were measured by immunoblotting in peripheral blood mononuclear cells (PBMC) of 47 OSAS patients and 17 healthy controls. Results: OSAS patients showed significantly lower PBMC ROCK1 and ROCK2 levels than healthy controls in the morning, but not in the evening. ROCK1/2 levels were correlated with blood triglyceride, visceral adiposity index, minimum oxygen saturation, C-reactive protein concentration, lymphocyte levels and sleep efficiency. Conclusion: Intermittent hypoxia induced by OSAS does not permanently alter ROCK protein expression levels. OSAS appears to be associated with endothelial dysfunction through inflammation and lipid metabolism pathways.