Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis


Fraser S., Diss J., Chioni A., Mycielska M., Pan H., Yamaci R., ...More

CLINICAL CANCER RESEARCH, vol.11, no.15, pp.5381-5389, 2005 (Journal Indexed in SCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 15
  • Publication Date: 2005
  • Doi Number: 10.1158/1078-0432.ccr-05-0327
  • Title of Journal : CLINICAL CANCER RESEARCH
  • Page Numbers: pp.5381-5389

Abstract

Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral to metastasis (e.g., proliferation, motility, secretion, and invasion), although their contribution to cancer progression has largely been ignored. The purpose of this study was to investigate voltage-gated Na(+) channel (VGSC) expression and its possible role in human breast cancer.