Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis


Fraser S., Diss J., Chioni A., Mycielska M., Pan H., Yamaci R., ...Daha Fazla

CLINICAL CANCER RESEARCH, cilt.11, ss.5381-5389, 2005 (SCI İndekslerine Giren Dergi) identifier identifier identifier identifier

  • Cilt numarası: 11 Konu: 15
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1158/1078-0432.ccr-05-0327
  • Dergi Adı: CLINICAL CANCER RESEARCH
  • Sayfa Sayıları: ss.5381-5389

Özet

Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral to metastasis (e.g., proliferation, motility, secretion, and invasion), although their contribution to cancer progression has largely been ignored. The purpose of this study was to investigate voltage-gated Na(+) channel (VGSC) expression and its possible role in human breast cancer.