Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis

Fraser, SP; Diss, JKJ; Chioni, AM; Mycielska, ME; Pan, HY; Yamaci, RF; Pani, F; Siwy, Z; Krasowska, M; Grzywna, Z; Brackenbury, WJ; Theodorou, D; Koyuturk, Meral; Kaya, H; Battaloglu, E; De Bella, MT; Slade, MJ; Tolhurst, R; Palmieri, C; Jiang, J; Latchman, DS; Coombes, RC; Djamgoz, MBA

doi:10.1158/1078-0432.ccr-05-0327

Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis

Fraser S., Diss J., Chioni A., Mycielska M., Pan H., Yamaci R., ...More

CLINICAL CANCER RESEARCH, vol.11, no.15, pp.5381-5389, 2005 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 11 Issue: 15
Publication Date: 2005
Doi Number: 10.1158/1078-0432.ccr-05-0327
Journal Name: CLINICAL CANCER RESEARCH
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.5381-5389
Istanbul University Affiliated: No

Abstract

Purpose: Ion channel activity is involved in several basic cellular behaviors that are integral to metastasis (e.g., proliferation, motility, secretion, and invasion), although their contribution to cancer progression has largely been ignored. The purpose of this study was to investigate voltage-gated Na(+) channel (VGSC) expression and its possible role in human breast cancer.