An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women

Mutlu-Turkoglu U., Oztezcan S., Telci A. G. S., Orhan Y., Aykac-Toker G., Sivas A., ...More

CLINICAL AND EXPERIMENTAL MEDICINE, vol.2, no.4, pp.171-174, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 2 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1007/s102380300002
  • Journal Name: CLINICAL AND EXPERIMENTAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.171-174
  • Keywords: obesity, women, lipoprotein oxidation, antioxidant activity, serum, LOW-DENSITY-LIPOPROTEIN, ANTIOXIDANT ACTIVITY, PROTEIN OXIDATION, SUSCEPTIBILITY, VITAMIN, PLASMA, LDL
  • Istanbul University Affiliated: Yes

Abstract

Endogenous malondialdehyde and diene conjugate levels, the susceptibility of apolipoprotein B-containing lipoproteins to copper-induced lipid peroxidation, and antibody titer against oxidized low-density lipoproteins were increased, but serum antioxidant activity was unchanged in obese women. Serum cholesterol, low-density lipoprotein-cholesterol, and trigliceride levels were also elevated, but high-density lipoprotein-cholesterol levels remained unchanged in obese women. In vitro, oxidation of apolipoprotein B-containing lipoproteins and levels of antibody against oxidized low-density lipoprotein correlated with body mass index, serum total cholesterol, and low-density lipoprotein-cholesterol levels in obese women. These results indicate that obesity is associated with increases in endogenous lipid peroxides, oxidation of low-density lipoproteins, and lipids in serum.