An increase in lipoprotein oxidation and endogenous lipid peroxides in serum of obese women

Mutlu-Turkoglu U., Oztezcan S., Telci A. G. S., Orhan Y., Aykac-Toker G., Sivas A., ...Daha Fazla

CLINICAL AND EXPERIMENTAL MEDICINE, cilt.2, sa.4, ss.171-174, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 2 Sayı: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1007/s102380300002
  • Dergi Adı: CLINICAL AND EXPERIMENTAL MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.171-174
  • Anahtar Kelimeler: obesity, women, lipoprotein oxidation, antioxidant activity, serum, LOW-DENSITY-LIPOPROTEIN, ANTIOXIDANT ACTIVITY, PROTEIN OXIDATION, SUSCEPTIBILITY, VITAMIN, PLASMA, LDL
  • İstanbul Üniversitesi Adresli: Evet

Özet

Endogenous malondialdehyde and diene conjugate levels, the susceptibility of apolipoprotein B-containing lipoproteins to copper-induced lipid peroxidation, and antibody titer against oxidized low-density lipoproteins were increased, but serum antioxidant activity was unchanged in obese women. Serum cholesterol, low-density lipoprotein-cholesterol, and trigliceride levels were also elevated, but high-density lipoprotein-cholesterol levels remained unchanged in obese women. In vitro, oxidation of apolipoprotein B-containing lipoproteins and levels of antibody against oxidized low-density lipoprotein correlated with body mass index, serum total cholesterol, and low-density lipoprotein-cholesterol levels in obese women. These results indicate that obesity is associated with increases in endogenous lipid peroxides, oxidation of low-density lipoproteins, and lipids in serum.