Functionally Overlapping Roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the Elimination of Methotrexate and Its Main Toxic Metabolite 7-Hydroxymethotrexate In vivo

Vlaming, Maria; Pala, Zeliha; van Esch, Anita; Wagenaar, Els; de Waart, Dirk; van de Wetering, Koen; van der Kruijssen, Cornelia; Elferink, Ronald; van Tellingen, Olaf; Schinkel, Alfred

doi:10.1158/1078-0432.ccr-08-2940

Functionally Overlapping Roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the Elimination of Methotrexate and Its Main Toxic Metabolite 7-Hydroxymethotrexate In vivo

Vlaming M. L. H., Pala Z., van Esch A., Wagenaar E., de Waart D. R., van de Wetering K., ...Daha Fazla

CLINICAL CANCER RESEARCH, cilt.15, sa.9, ss.3084-3093, 2009 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 15 Sayı: 9
Basım Tarihi: 2009
Doi Numarası: 10.1158/1078-0432.ccr-08-2940
Dergi Adı: CLINICAL CANCER RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.3084-3093
İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: ABCC2 (MRP2) and ABCG2 (BCRP) transport various endogenous and exogenous compounds, including many anticancer drugs, into bile, feces, and urine. We investigated the possibly overlapping roles of Abcg2 and Abcc2 in the elimination of the anticancer drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX).