Atıf İçin Kopyala
Vlaming M. L. H., Pala Z., van Esch A., Wagenaar E., de Waart D. R., van de Wetering K., ...Daha Fazla
CLINICAL CANCER RESEARCH, cilt.15, sa.9, ss.3084-3093, 2009 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
15
Sayı:
9
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Basım Tarihi:
2009
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Doi Numarası:
10.1158/1078-0432.ccr-08-2940
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Dergi Adı:
CLINICAL CANCER RESEARCH
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.3084-3093
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İstanbul Üniversitesi Adresli:
Evet
Özet
Purpose: ABCC2 (MRP2) and ABCG2 (BCRP) transport various endogenous and exogenous compounds, including many anticancer drugs, into bile, feces, and urine. We investigated the possibly overlapping roles of Abcg2 and Abcc2 in the elimination of the anticancer drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX).