Variant Philadelphia translocations with different breakpoints in six chronic myeloid leukemia patients

Kuru, Dilhan; Arguden, Yelda; Ar, Muhlis; Cirakoglu, Ayse; Ongoren, Seniz; Yilmaz, Sukriye; Eskazan, Ahmet; Deviren, Ayhan; Soysal, Teoman; Hacihanefioglu, Seniha; Ulku, Birsen

doi:10.5152/tjh.2011.52

Variant Philadelphia translocations with different breakpoints in six chronic myeloid leukemia patients

Kuru D., Arguden Y. T., Ar M. C., Cirakoglu A., Ongoren S., Yilmaz S., ...Daha Fazla

TURKISH JOURNAL OF HEMATOLOGY, cilt.28, sa.3, ss.186-192, 2011 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 28 Sayı: 3
Basım Tarihi: 2011
Doi Numarası: 10.5152/tjh.2011.52
Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.186-192
İstanbul Üniversitesi Adresli: Evet

Özet

Objective: The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11) translocation, is observed in similar to 90% of patients with chronic myeloid leukemia (CML). Variant Ph translocations are observed in 5%-40% of CML patients. In variant translocations 3 and possibly more chromosomes are involved. Herein we report 6 CML patients with variant Ph translocations.