Variant Philadelphia translocations with different breakpoints in six chronic myeloid leukemia patients

Kuru, Dilhan; Arguden, Yelda; Ar, Muhlis; Cirakoglu, Ayse; Ongoren, Seniz; Yilmaz, Sukriye; Eskazan, Ahmet; Deviren, Ayhan; Soysal, Teoman; Hacihanefioglu, Seniha; Ulku, Birsen

doi:10.5152/tjh.2011.52

Variant Philadelphia translocations with different breakpoints in six chronic myeloid leukemia patients

Kuru D., Arguden Y. T., Ar M. C., Cirakoglu A., Ongoren S., Yilmaz S., ...More

TURKISH JOURNAL OF HEMATOLOGY, vol.28, no.3, pp.186-192, 2011 (SCI-Expanded, Scopus, TRDizin)

Publication Type: Article / Article
Volume: 28 Issue: 3
Publication Date: 2011
Doi Number: 10.5152/tjh.2011.52
Journal Name: TURKISH JOURNAL OF HEMATOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Page Numbers: pp.186-192
Istanbul University Affiliated: Yes

Abstract

Objective: The Philadelphia (Ph) chromosome, consisting of the t(9;22)(q34;q11) translocation, is observed in similar to 90% of patients with chronic myeloid leukemia (CML). Variant Ph translocations are observed in 5%-40% of CML patients. In variant translocations 3 and possibly more chromosomes are involved. Herein we report 6 CML patients with variant Ph translocations.