Association of Cytokine Gene Polymorphisms (IL6, IL10, TNF-alpha, TGF-beta and IFN-gamma) and Graves' Disease in Turkish Population

KUTLUTÜRK F., Yarman S., Sarvan F., Kekik C.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, cilt.13, sa.2, ss.163-167, 2013 (SCI-Expanded, Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.2174/18715303113139990001
  • Dergi Adı: ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.163-167
  • Anahtar Kelimeler: Cytokine, graves' disease, interferon, interleukin, polymorphism, transforming growth factor, tumour necrosis factor, AUTOIMMUNE THYROID-DISEASE, TUMOR-NECROSIS-FACTOR, FUNCTIONAL POLYMORPHISMS, CHINESE POPULATION, RECEPTOR ANTIBODY, OPHTHALMOPATHY, INTERLEUKIN-6, PATHOGENESIS, PROMOTER, IL-6
  • İstanbul Üniversitesi Adresli: Evet

Özet

Introduction: Cytokines play a crucial role in the pathogenesis of autoimmune thyroid disease, and recent studies have demonstrated an association between cytokine gene polymorphisms and Graves' Disease (GD) in different ethnic groups. The aim of the present study was to investigate the relationship of interleukin-6 (IL-6), IL-10, tumor necrosis factor-alpha (TNF-alpha), transforming growth factor-beta (TGF-beta), and interferon-gamma (INF-gamma) gene polymorphisms in the development of GD in Turkish population.