Generalized prepubertal periodontitis - A report of 4 cases with the immunological findings
JOURNAL OF CLINICAL PERIODONTOLOGY, cilt.23, sa.12, ss.1104-1111, 1996 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 12
- Basım Tarihi: 1996
- Doi Numarası: 10.1111/j.1600-051x.1996.tb01811.x
- Dergi Adı: JOURNAL OF CLINICAL PERIODONTOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1104-1111
- İstanbul Üniversitesi Adresli: Evet
Özet
The clinical and immunological data from 4 patients with generalized prepubertal periodontitis are presented. The peripheral blood neutrophil chemotaxis taxis was measured using zymosan activated sera as the chemoattractant. All of the 4 patients have shown depressed neutrophil chemotaxis compared to those of the healthy controls. Peripheral blood lymphocyte subpopulations were analysed by double-coloured flow cytometry using monoclonal antibodies for the receptors CD2, CD3, CD4, CD8, CD19, CD29, CD45RA+, 34,29dK, CD56, CD11b/CD18. Lymphocytes bearing CD3 receptors showed a significant decrease compared to those of the controls. Natural killer cells were lowered in 3 of the 4 cases. All of the patients showed a higher increase in CD11b/CD18 expression. The evaluation of CD11b/CD18 receptor in peripheral blood leukocytes may be of help explaining the role uf neutrophils in the pathogenesis of the disease.