Hyperpigmentation due to pyrimethamine use

Ozturk R., Engin A., Ozaras R., Mert A., Tabak F., Aktuglu Y.

JOURNAL OF DERMATOLOGY, vol.29, no.7, pp.443-445, 2002 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 7
  • Publication Date: 2002
  • Doi Number: 10.1111/j.1346-8138.2002.tb00303.x
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.443-445
  • Istanbul University Affiliated: Yes


Pyrimethamine is used for the treatment of tuxoplasmosis and the prophylaxis of malaria. Among the well-documented side effects are megaloblastic anemia, leukopenia, thrombopenia, rash, vomiting, and diarrhea. Hyperpigmentation is a very rare side effect. In some patients, associated HIV infection makes it difficult to distinguish the reasons for the etiology. We herein describe an HIV-negative patient who developed hyperpigmentation after pyrimethamine use.