Brominated sesquiterpenes from the red alga Laurencia obtusa

Topcu G., Aydogmus Z., Imre S., Goren A., Pezzuto J., Clement J., ...More

JOURNAL OF NATURAL PRODUCTS, vol.66, no.11, pp.1505-1508, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 11
  • Publication Date: 2003
  • Doi Number: 10.1021/np030176p
  • Journal Name: JOURNAL OF NATURAL PRODUCTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1505-1508
  • Istanbul University Affiliated: Yes

Abstract

Four new sesquiterpenes, (8R*)-8-bromo-10-epi-beta-snyderol (1), (8S*)-8-bromo-beta-snyderol (2), 5-bromo-3-(3'-hydroxy-3'-methylpent-4'-enylidene)-2,4,4-trimethylcyclohexanone (3), and the epoxide 4, have been isolated from the chloroform-methanol extract of Laurencia obtusa, together with the three known compounds alpha-snyderol (5), alpha-snyderol acetate (6), and stigmasterol. The structures of the isolated compounds were elucidated through spectroscopic analyses. Compound 1 showed antimalarial activity, with IC50 values of 2700 and 4000 ng/mL against the D6 and W2 clones of Plasmodium falciparum, respectively.