Cyclooxygenase-2 gene and epithelial ovarian carcinoma risk
MOLECULAR BIOLOGY REPORTS, vol.38, no.5, pp.3481-3486, 2011 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 38 Issue: 5
- Publication Date: 2011
- Doi Number: 10.1007/s11033-010-0458-7
- Journal Name: MOLECULAR BIOLOGY REPORTS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.3481-3486
- Keywords: Cox-2, Epithelial ovarian carcinoma, Polymorphism, NITRIC-OXIDE SYNTHASE, MESSENGER-RNA EXPRESSION, PROGNOSTIC-SIGNIFICANCE, COLORECTAL-CANCER, LUNG-CARCINOMA, GROWTH-FACTOR, POLYMORPHISM, ADENOCARCINOMAS, ANGIOGENESIS, ASSOCIATION
- Istanbul University Affiliated: Yes
Abstract
In this study, we aimed to investigate a possible association of the COX-2 polymorphisms (-765G -> C and -1195A -> G) and with the risk of developing epithelial ovarian carcinoma (EOC). COX-2 gene polymorphisms was investigated in 111 healthy women and 57 patients with EOC. Individuals who had -765 CG, -1195 AA genotype, and -765 C allele had increased risk for ovarian carcinoma (P < 0.01) and individuals with -765 GG, -1195 AG genotypes and -1195 G allele seem to be protected from ovarian carcinoma (P < 0.01). Haplotype analysis confirmed the association of COX-2 gene variants with ovarian carcinoma and revealed that the frequencies of -765C: -1195A haplotype frequencies was significantly higher in patients as compared with those of controls (P = 0.048). We state that there appears to be a modulating role for the COX-2 -1195A -> G and -765G -> C polymorphisms in the development of EOC. To the best of our knowledge, this is the first study to show such an association.