First year real life experience with tenofovir alafenamide fumarate: The pythagorean cohort


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KARAŞAHİN Ö., KALKAN İ. A., DAL T., TOPLU S., HARPUTLUOĞLU M. M., METE A. O., ...More

Hepatology forum, vol.4, no.2, pp.61-68, 2023 (ESCI) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 2
  • Publication Date: 2023
  • Doi Number: 10.14744/hf.2022.2022.0043
  • Journal Name: Hepatology forum
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.61-68
  • Istanbul University Affiliated: Yes

Abstract

Background and Aim: In chronic hepatitis B infection, antiviral therapy significantly reduces the incidence of complications. This study aimed to present real-life 12-month effectiveness and safety data for TAF. Materials and Methods: This Pythagoras Retrospective Cohort Study in cluded patients from 14 centers in Turkiye. The study presents 12-month results of 480 patients treated with TAF as initial therapy or after switching from another antiviral drug. Results: The study shows treatment of about 78.1% patients with at least one antiviral agent (90.6% tenofovir disoproxil [TDF]). The rate of unde tectable HBV DNA increased in both treatment-experienced and naive pa tients. In TDF-experienced patients, the rate of alanine transaminase (ALT) normalization increased slightly (1.6%) within 12 months, but the change was not statistically significant (p=0.766). Younger age, low albumin, and high body mass index and cholesterol were identified as risk factors for abnormal ALT after 12 months, but no linear relationship was detected. In TDF-experienced patients, renal and bone function indicators showed sig nificant improvement three months after the transition to TAF and remained stable for 12 months. Conclusion: Real-life data demonstrated effective virological and bio chemical responses with TAF therapy. After switching to TAF treat ment, gains in kidney and bone functions were achieved in the early period.