Synthesis and antimycobacterial activity of new 2-hydroxy-N-(3-oxo-1-thia-4-azaspiro[4.4]non-4-yl)/(3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl)-2,2-diphenylacetamide derivatives


Guezel O., Ithan E., Salman A.

MONATSHEFTE FUR CHEMIE, cilt.137, ss.795-801, 2006 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 137 Konu: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1007/s00706-006-0475-3
  • Dergi Adı: MONATSHEFTE FUR CHEMIE
  • Sayfa Sayıları: ss.795-801

Özet

2-Hydroxy-2,2-diphenylacetohydrazide (2), cyclic ketones, and mercaptoalkanoic acids were converted into 2-hydroxy-N-(3-oxo-1-thia-4-azaspiro[4.4] non/ [4.5] dee-4-yl)-2,2-diphenylacetamide derivatives (3, 4) in a one pot procedure. Compounds 3 and 4 were tested for in vitro antimycobacterial activity against M. tuberculosis H37Rv. The compounds were found to provide 0-86% inhibition of mycobacterial growth in the primary screen conducted at 6.25 mu g/cm(3).