Synthesis and antimycobacterial activity of new 2-hydroxy-N-(3-oxo-1-thia-4-azaspiro[4.4]non-4-yl)/(3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl)-2,2-diphenylacetamide derivatives

Guezel, Oezlen; Ithan, Eser; Salman, Aydin

doi:10.1007/s00706-006-0475-3

Synthesis and antimycobacterial activity of new 2-hydroxy-N-(3-oxo-1-thia-4-azaspiro[4.4]non-4-yl)/(3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl)-2,2-diphenylacetamide derivatives

Atıf İçin Kopyala

Guezel O., Ithan E., Salman A.

MONATSHEFTE FUR CHEMIE, cilt.137, sa.6, ss.795-801, 2006 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 137 Sayı: 6
Basım Tarihi: 2006
Doi Numarası: 10.1007/s00706-006-0475-3
Dergi Adı: MONATSHEFTE FUR CHEMIE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.795-801
İstanbul Üniversitesi Adresli: Hayır

Özet

2-Hydroxy-2,2-diphenylacetohydrazide (2), cyclic ketones, and mercaptoalkanoic acids were converted into 2-hydroxy-N-(3-oxo-1-thia-4-azaspiro[4.4] non/ [4.5] dee-4-yl)-2,2-diphenylacetamide derivatives (3, 4) in a one pot procedure. Compounds 3 and 4 were tested for in vitro antimycobacterial activity against M. tuberculosis H37Rv. The compounds were found to provide 0-86% inhibition of mycobacterial growth in the primary screen conducted at 6.25 mu g/cm(3).