Synthesis and antimycobacterial activity of new 2-hydroxy-N-(3-oxo-1-thia-4-azaspiro[4.4]non-4-yl)/(3-oxo-1-thia-4-azaspiro[4.5]dec-4-yl)-2,2-diphenylacetamide derivatives


Guezel O., Ithan E., Salman A.

MONATSHEFTE FUR CHEMIE, vol.137, no.6, pp.795-801, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 137 Issue: 6
  • Publication Date: 2006
  • Doi Number: 10.1007/s00706-006-0475-3
  • Journal Name: MONATSHEFTE FUR CHEMIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.795-801
  • Istanbul University Affiliated: No

Abstract

2-Hydroxy-2,2-diphenylacetohydrazide (2), cyclic ketones, and mercaptoalkanoic acids were converted into 2-hydroxy-N-(3-oxo-1-thia-4-azaspiro[4.4] non/ [4.5] dee-4-yl)-2,2-diphenylacetamide derivatives (3, 4) in a one pot procedure. Compounds 3 and 4 were tested for in vitro antimycobacterial activity against M. tuberculosis H37Rv. The compounds were found to provide 0-86% inhibition of mycobacterial growth in the primary screen conducted at 6.25 mu g/cm(3).