Almost Complete Response with a Single Administration Ac-225-DOTATATE in a Patient with a Metastatic Neuroendocrine Tumor of Unknown Primary

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ALAN SELÇUK N., Demirci E., Ocak M., Toklu T., Ergen S., KABASAKAL L.

MOLECULAR IMAGING AND RADIONUCLIDE THERAPY, cilt.31, sa.2, ss.139-141, 2022 (ESCI)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 31 Sayı: 2
• Basım Tarihi: 2022
• Doi Numarası: 10.4274/mirt.galenos.2022.64497
• Dergi Adı: MOLECULAR IMAGING AND RADIONUCLIDE THERAPY
• Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.139-141
• Anahtar Kelimeler: Ac-225 targeted alpha therapy, neuroendocrine tumors, peptide receptor radionuclide therapy
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• İstanbul Üniversitesi Adresli: Evet

Özet

Neuroendocrine tumors (NETS) are being seen increasingly frequently, and the only known curative treatment method is surgical resection. Peptide receptor radionuclide therapy (PRRT) is a treatment option that the most contributes to progression-free survival and overall survival in metastatic cases.beta-emitting radionuclides are traditionally used for PRRT. Nowadays, alpha particle-emitting radionuclides are being developed, with advantages in terms of very high energy and a short path length, which should theoretically show higher efficacy. In this case; in a patient with NET diagnosis who had multiple (>50) lesions in the abdomen, almost all the lesions disappeared with a single dose application. This paper aims to present a case in which we observed the efficacy of Ac-225-DOTATATE treatment, which is an alpha treatment.