Investigation of dehydroepiandrosterone induced in vitro physiological effects in human endothelial and ovarian cancer cells

GÜNDOĞAN G. İ., KIĞ C., KARACAN M., DOĞRUMAN H.

Turkish Journal of Pharmaceutical Sciences, cilt.18, sa.02, ss.185-191, 2021 (ESCI) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 02
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4274/tjps.galenos.2020.58827
  • Dergi Adı: Turkish Journal of Pharmaceutical Sciences
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.185-191
  • Anahtar Kelimeler: Dehydroepiandrosterone, MDAH-2774, HuVeC, ovarian cancer, BREAST-CANCER, ANDROGEN-RECEPTOR, BONE-MARROW, IN-VITRO, PROLIFERATION, DHEA, MIGRATION, INHIBITION, METABOLISM, EXPRESSION
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Objectives: Dehydroepiandrosterone (DHEA) is an endogenous hormone that acts as a ligand for several cellular receptors. An age-dependent decline in circulating levels of DHEA is linked to changes in various physiological functions. In gynecological clinical practice, DHEA is commonly prescribed to induce ovulation. Some clinical studies report a positive association between high serum concentrations of DHEA and an increased risk of developing ovarian cancer. However, the in vitro physiological effects of DHEA on ovarian cancerous cells have not been explored thus far. In this study, we aimed to investigate the physiological effects of DHEA treatment (0-200 mu M, 24-72 hours) on MDAH-2774 human ovarian cancer cell line and primary HuVeC human endothelial cells.