Research Information System
34th Annual Meeting of the ASRI, Long Beach, NY, Newyork, United States Of America, 2 - 05 June 2014, vol.71, no.1, pp.31, (Full Text)
Abstract: Aim: Little is known about the role some cytokines and cells (like IL-12, IL-17, Foxp3 +Treg, NK) in postmenopause. In the present study we investigated Th1 and Th2 cytokines with especially focusing on IL-17 producing and Foxp3 + regulatory cells(Treg) and to compare between cytokines levels changing in postmenopausal women. Methods: Blood samples were taken from fertile women (were used as controls, ages 29±5) and postmenopausal women (ages 62,1±3) (≥10 years, since their last menstruation). Percentage of NK (CD56) ve Foxp3+Treg cell were measured by flow cytometry and cytokines IL-4, IL-6, IL-10, IL-12, IL-1β, TNF-α, IL-2, IFN-γ, IL-17 were measured by ELISA. Statistical Analysis: One way ANOVA followed by Tukey HSD. A value of p < 0.05 was considered to indicate statistical significance. Results: Levels of IL-4, IL-6, IL-12, IL-1β, IL-17 and NK(CD56) in postmenopausal women were significantly increased than in fertile women. However IL-2 and IL-10 were significantly lower in the postmenopausal women than that of controls. TNF-α, IFN-γ and Foxp3+Treg were not different between two groups. Conclusion: According to our results, increased innate immunity and Th1 and Th17 mediated adaptive immunity inpostmenopausal women may explain increasing prevalance of chronic inflammatory diseases in postmenopause.