Association of CYP2D6*4 gene polymorphism with early papillary thyroid carcinoma

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Aday A. D., Ozturk T., Teker B. A., Aksoy F., Aydogan H. Y., ÖZTÜRK O., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.46, no.4, pp.455-460, 2021 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 4
  • Publication Date: 2021
  • Doi Number: 10.1515/tjb-2020-0103
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.455-460
  • Keywords: CYP2D6, papillary thyroid carcinoma, polymorphism, rs3892097, xenobiotic, CYP2D6 GENE, SUSCEPTIBILITY, CYTOCHROME-P450, IDENTIFICATION, MARKERS, DEFECT, GSTM1, GSTT1
  • Istanbul University Affiliated: Yes

Abstract

Objectives: CYP2D6 is highly polymorphic and a common variant CYP2D6*4 results in the generation of poor metabolizer enzyme. The CYP2D6*4 variant has been associated with altered susceptibility to several cancers. The aim of the present case-control study aims to investigate the association between CYP2D6*4 polymorphism and the risk of papillary thyroid carcinoma (PTC).