Association of CYP2D6*4 gene polymorphism with early papillary thyroid carcinoma
TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.46, sa.4, ss.455-460, 2021 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 46 Sayı: 4
- Basım Tarihi: 2021
- Doi Numarası: 10.1515/tjb-2020-0103
- Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, Food Science & Technology Abstracts, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.455-460
- Anahtar Kelimeler: CYP2D6, papillary thyroid carcinoma, polymorphism, rs3892097, xenobiotic, CYP2D6 GENE, SUSCEPTIBILITY, CYTOCHROME-P450, IDENTIFICATION, MARKERS, DEFECT, GSTM1, GSTT1
- İstanbul Üniversitesi Adresli: Evet
Özet
Objectives: CYP2D6 is highly polymorphic and a common variant CYP2D6*4 results in the generation of poor metabolizer enzyme. The CYP2D6*4 variant has been associated with altered susceptibility to several cancers. The aim of the present case-control study aims to investigate the association between CYP2D6*4 polymorphism and the risk of papillary thyroid carcinoma (PTC).