Does pendimethalin develop in pancreatic cancer induced inflammation?

Arici M., Abudayyak M. F., Boran T., Özhan G.

Chemosphere, cilt.252, ss.126644, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 252
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.chemosphere.2020.126644
  • Dergi Adı: Chemosphere
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Artic & Antarctic Regions, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Environment Index, Food Science & Technology Abstracts, Geobase, Greenfile, MEDLINE, Metadex, Pollution Abstracts, Public Affairs Index, Veterinary Science Database, Civil Engineering Abstracts
  • Sayfa Sayıları: ss.126644
  • Anahtar Kelimeler: Sunitinib, Hepatotoxicity, Mitochondrial toxicity, Reactive oxygen species (ROS), Apoptosis, PGC-1 alpha, TYROSINE KINASE INHIBITOR, LIVER-MITOCHONDRIA, ANTITUMOR-ACTIVITY, OXIDATIVE STRESS, GROWTH-FACTOR, HUMAN PLASMA, COMPLEX-III, CELL-DEATH, SU11248, RATS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Pendimethalin, one of the dinitroaniline group herbicides, is applied for controlling weeds in cereals,legumes and vegetable crops, and has been classified as possible human carcinogen. It is indicated thatpendimethalin should arise risks of developing some cancer types; however, there is no data on theeffects of pendimethalin on pancreatic cancer-induced inflammation. Injuries resulting from by acutepancreatitis attacks and inflammation are significant factors in the development of pancreatic cancer.Therefore, we investigated whether pendimethalin triggers inflammation as a mechanism of pancreaticcancer development. Parameters related to pancreatic activation, oxidative stress, and inflammationwere measured in the human pancreatic (PANC-1) cell line. In the range of 0e100mM, the levels ofchymotrypsin decreased. It should be indicated that the reason for the decrease in chymotrypsin may bethe high rates of cell death (20%) observed in the high concentration levels. We observed that pendi-methalin significantly induced oxidative damage, while levels of interleukin-6 (IL-6) and interleukin-8(IL-8) did not change. The obtained results may draw attention to the usage and possible toxic effectof pendimethalin due to oxidative damage induction; however, detailed inflammation mechanisms andother cancer pathways should be investigated.