Cytotoxic activities of new iron(III) and nickel(II) chelates of some S-methyl-thiosemicarbazones on K562 and ECV304 cells

Atasever B., Ulkuseven B., Bal-Demirci T., Erdem-Kuruca S., Solakoglu Z.

INVESTIGATIONAL NEW DRUGS, cilt.28, sa.4, ss.421-432, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 4
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1007/s10637-009-9272-2
  • Dergi Adı: INVESTIGATIONAL NEW DRUGS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.421-432
  • Anahtar Kelimeler: Thiosemicarbazone, Iron complex, Nickel complex, Cytotoxicity, MTT, RIBONUCLEOTIDE REDUCTASE INHIBITOR, SELECTIVE ANTITUMOR-ACTIVITY, TRANSITION-METAL-COMPLEXES, ANTI-HIV ACTIVITY, COPPER(II) COMPLEXES, IN-VITRO, PALLADIUM(II) COMPLEXES, ANTIMYCOBACTERIAL ACTIVITY, SPECTRAL CHARACTERIZATION, BIOLOGICAL-ACTIVITY
  • İstanbul Üniversitesi Adresli: Evet

Özet

The S-methyl-thiosemicarbazones of the 2-hydroxy-R-benzaldehyde (R= H, 3-OH 3-OCH3 or 4-OCH3) reacted with the corresponding aldehydes in the presence of FeCl3 and NiCl2. New ONNO chelates of iron(III) and nickel(II) with hydroxy- or methoxy-substitued N (1),N (4)-diarylidene-S-methyl-thiosemicarbazones were characterized by means of elemental analysis, conductivity and magnetic measurements, UV-Vis, IR and H-1-NMR spectroscopies. Cytotoxic activities of the compounds were determined using K562 chronic myeloid leukemia and ECV304 human endothelial cell lines by MTT assay. It was determined that monochloro N (1)-4-methoxysalicylidene-N (4)-4-methoxysalicylidene-S-methyl-thiosemicarbazidato-iron(III) complex showed selective anti-leukemic effects in K562 cells while has no effect in ECV304 cells in the 0.53 mu g/ml (IC50) concentrations. Also, some methoxy-substitued nickel(II) chelates exhibit high cytotoxic activitiy against both of these cell lines in low concentrations. Cytotoxicity data were evaluated depending on cell lines origin and position of the substituents on aromatic rings.