Synthesis and antimicrobial properties of new 4-(alkylidene/arylidene)-amino-5-(2-furanyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones and 6-aryl-3-(2-furanyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines

Ergenc N., Ulusoy N., Capan G., Sanis G., Kiraz M.

ARCHIV DER PHARMAZIE, cilt.329, ss.427-430, 1996 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 329
  • Basım Tarihi: 1996
  • Doi Numarası: 10.1002/ardp.19963290811
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.427-430
  • İstanbul Üniversitesi Adresli: Evet

Özet

A series of 4-(alkylidene/arylidene)amino-5-(2-furanyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones (2) and 6-aryl-3-(2-furanyl)-7H-1,2,4-triazolo[3,4-b][1,3,4] thiadiazines (3) were synthesized. The configuration of 2g was assigned on the basis of H-1-NMR data. Of the new derivatives tested, only 2b, 2g, and 4f were found to be active against Staphylococcus aureus and/or Staphylococcus epidermidis (MIC 125-1.95 mu g/ml), whereas all exhibited varying degrees of antifungal activity (MIC 25-0.8 mu g/ml).