Serum levels of arginase I are associated with left ventricular function after myocardial infarction


Bekpinar S., Gurdol F., Unlucerci Y., Develi S., Yilmaz A.

CLINICAL BIOCHEMISTRY, vol.44, no.13, pp.1090-1093, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 44 Issue: 13
  • Publication Date: 2011
  • Doi Number: 10.1016/j.clinbiochem.2011.06.003
  • Journal Name: CLINICAL BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1090-1093
  • Istanbul University Affiliated: Yes

Abstract

Objectives: Upregulation of arginase redirects the arginine metabolism from nitric oxide (NO) synthesis to the formation of polyamine and proline, thus causing cardiac dysfunction. NO synthesis is also impaired by asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor. We aimed to evaluate the impact of arginase and ADMA levels on left ventricular function after myocardial infarction (MI).