Clinical course of ocular Behcet's disease in siblings

Onal S., Tuga-Tutkun I., Urgancioglu M., Gul A.

OCULAR IMMUNOLOGY AND INFLAMMATION, cilt.9, sa.2, ss.111-124, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 2
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1076/ocii.9.2.111.3971
  • Dergi Adı: OCULAR IMMUNOLOGY AND INFLAMMATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.111-124
  • Anahtar Kelimeler: Behcet's disease, eye involvement, familial occurrence, siblings, CLOSE ASSOCIATION, HLA ANTIGENS, TURKEY, PREVALENCE, INVOLVEMENT, FEATURES, HLA-B51, ONSET, AGE, SEX
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: Familial occurrence has been reported in approximately 8% of Turkish patients with Behcet's disease. Our aim was to compare the clinical course of ocular Behcet's disease among siblings. Methods: We retrospectively studied five pairs of siblings with ocular involvement of Behcet's disease. No other family member of these siblings had any symptom of Behcet's disease. Results: The siblings comprised three sister-brother pairs, one sister-sister pair, and one brother-brother pair. There was a 5-10-year difference between the age at onset of ocular disease among siblings. Three of the five pairs (two sister-brother, one brother-brother) had a dissimilar course of disease activity. Female siblings had an earlier age at onset and tended to have a worse prognosis than their brothers. Conclusions: It is generally acknowledged that male sex is associated with a worse prognosis. In this study, however, we observed that, among siblings with a dissimilar course, female patients were more severely affected than male patients. Poor ocular prognosis in a patient does not indicate aggressive treatment in his/her sibling. We believe that each sibling should be managed on an individual basis.