Factor V Leiden, prothrombin G20210A and protein C mutation frequency in Turkish venous thrombosis patients

Altinisik J., Ates O., Ulutin T., Cengiz M., Buyru N.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, cilt.14, sa.4, ss.415-420, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 4
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1177/1076029607306404
  • Dergi Adı: CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.415-420
  • İstanbul Üniversitesi Adresli: Evet

Özet

Several inherited polymorphisms are associated with risk of venous thrombosis, including Mutation at codon 506 of the factor V gene, mutation at position 20210 of the prothrombin gene, and mutations in the protein C gene. In this study, genotyping for factor V, prothrombin, and protein C Mutations was performed in 50 patients and 25 control Subjects by polymerase chain reaction-based analysis. The prevalence of factor V and prothrombin mutations was not significantly different from that in the general population. Nine Of the patients had heterozygous protein C mutation. There was a high prevalence of the Mutated protein C allele in the Pulmonary emboli group (42.8%). Protein C mutation incidence was higher in the pulmonary emboli group than in the deep vein thrombosis (8.33%) and cerebral vein thrombosis (16.1%) groups. These results indicate that patients with protein C deficiency have a greater risk of thrombosis than patients with factor V or prothrombin G20210A mutation.