Factor V Leiden, prothrombin G20210A and protein C mutation frequency in Turkish venous thrombosis patients


Altinisik J., Ates O., Ulutin T., Cengiz M. , Buyru N.

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, vol.14, no.4, pp.415-420, 2008 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 4
  • Publication Date: 2008
  • Doi Number: 10.1177/1076029607306404
  • Title of Journal : CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
  • Page Numbers: pp.415-420

Abstract

Several inherited polymorphisms are associated with risk of venous thrombosis, including Mutation at codon 506 of the factor V gene, mutation at position 20210 of the prothrombin gene, and mutations in the protein C gene. In this study, genotyping for factor V, prothrombin, and protein C Mutations was performed in 50 patients and 25 control Subjects by polymerase chain reaction-based analysis. The prevalence of factor V and prothrombin mutations was not significantly different from that in the general population. Nine Of the patients had heterozygous protein C mutation. There was a high prevalence of the Mutated protein C allele in the Pulmonary emboli group (42.8%). Protein C mutation incidence was higher in the pulmonary emboli group than in the deep vein thrombosis (8.33%) and cerebral vein thrombosis (16.1%) groups. These results indicate that patients with protein C deficiency have a greater risk of thrombosis than patients with factor V or prothrombin G20210A mutation.