The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism

DİKENSOY, EBRU; Balat, Ozcan; PENÇE, Sadrettin; AKÇALI, CENK; ÇİÇEK, HÜLYA

doi:10.1007/s00404-008-0719-z

The risk of hepatotoxicity during long-term and low-dose flutamide treatment in hirsutism

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DİKENSOY E., Balat O., PENÇE S., AKÇALI C., ÇİÇEK H.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS, vol.279, no.3, pp.321-327, 2009 (SCI-Expanded)

Publication Type: Article / Article
Volume: 279 Issue: 3
Publication Date: 2009
Doi Number: 10.1007/s00404-008-0719-z
Journal Name: ARCHIVES OF GYNECOLOGY AND OBSTETRICS
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.321-327
Istanbul University Affiliated: No

Abstract

Flutamide is an effective drug in treatment of hirsutism. Hepatotoxicity occasionally may occur with therapeutic doses (750-1500 mg/day), 3 months after initiation of treatment. Monitoring of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels is recommended to obviate serious hepatotoxicity.