HLA-A, B, C, DRB1 and DQB1 allele and haplotype frequencies in volunteer bone marrow donors from Eastern Region of Saudi Arabia

Jawdat D., Al-Zahrani M., Al-Askar A., Fakhoury H., Uyar F. A., Hajeer A.

HLA, cilt.94, sa.1, ss.49-56, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 94 Sayı: 1
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1111/tan.13533
  • Dergi Adı: HLA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.49-56
  • Anahtar Kelimeler: alleles, haplotypes, HLA, Saudi Arabia, CLASS-I, POPULATIONS, GENES
  • İstanbul Üniversitesi Adresli: Evet

Özet

We analyzed HLA allele and haplotype frequencies from donors from the Eastern region of Saudi Arabia. A cross-sectional study was performed on 2405 bone marrow donors from the Eastern region. HLA typing was carried out by sequencing. The most common HLA allele groups were HLA-A*02:01:01G (11.08%), A*01:01:01G (10.40%), HLA-B*52:01:01G (8.79%), B*18:01:01G (8.07%), HLA-C*04:01:01G (17.88%), C*12:03:01G (10.23%), HLA-DRB1*10:01 (14.89%), DRB1*03:01:01G (14.10%), HLA-DQB1*02:01:01G (24.53%) and DQB1*05:01:01G (20.17%). The most frequent HLA-A(center dot)C(center dot)B(center dot)DRB1(center dot)DQB1 haplotypes were HLA-A*01:03(center dot)C*15:05:01GB*73:01DRB1*10:01:01DQB1*05:01:01G (3.11%) and HLA-A*01:01:01GC*12:02:01GB*52:01:01GDRB1*15:02:01DQB1*06:01:01G (2.25%). When comparing the allele and haplotype frequencies of the Eastern regions' population to those from the Central region we found significant differences in several allele frequencies including A*01:01:01G (P <= 0.0001), B*52:01:01G (P <= 0.0001), B*18:01:01G (P = 0.0001), C*12:03:01G (P < 0.0001), DRB1*10:01:01 (P < 0.0001) and DQB1*05:01:01G (P < 0.0001). Our data confirms genetic heterogeneity among the Saudi population.