Evaluation of toxic effects of dapagliflozin on reproductive system in diabetic rats


Ulus Karaca B., Boran T., Karagöz Köroğlu A., ERCAN F., ÖZHAN G.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.52, no.4, pp.1362-1370, 2022 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 4
  • Publication Date: 2022
  • Doi Number: 10.55730/1300-0144.5443
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1362-1370
  • Keywords: Type-2 diabetes, dapagliflozin, male reproductive system, oxidative damage, GLUCOSE COTRANSPORTER 2, OXIDATIVE STRESS, MALE-FERTILITY, CHRONIC SAFETY, INHIBITOR, MELLITUS, PARAMETERS, MORPHOLOGY, APOPTOSIS, SPERM
  • Istanbul University Affiliated: Yes

Abstract

Background/aim: Dapagliflozin (DAPA), sodium-glucose cotransporter 2 (SGLT2) inhibitor, is an insulin-independent antidiabetic drug used to control hyperglycaemia by promoting glucose excretion from the kidney. Its adverse effects include orthostatic hypotension, dehydration and urinary tract and genital infections caused by glycosuria. DAPA is subjected to constant additional monitoring, as drug-related adverse reactions are frequently updated in line with the results of case studies, clinical trials and in vivo studies. Some antidiabetic drugs have shown potential harmful effects on the male reproductive system; however, the effects of DAPA have not been sufficiently studied in this capacity. Aiming to fill this gap in the literature, the present work investigates the toxic effects of DAPA on the male reproductive system.