Assessment of metabolic risk factors for nephrolithiasis in patients with autosomal dominant polycystic kidney disease: a cross-sectional study

Chasan O., Mirioglu S., ARTAN A. S., GÜRSU M., KAZANCIOĞLU R., ELÇİOĞLU Ö. C.

CLINICAL AND EXPERIMENTAL NEPHROLOGY, cilt.27, sa.11, ss.912-918, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 11
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1007/s10157-023-02378-2
  • Dergi Adı: CLINICAL AND EXPERIMENTAL NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, MEDLINE
  • Sayfa Sayıları: ss.912-918
  • Anahtar Kelimeler: Autosomal dominant, Hypocitraturia, Nephrolithiasis, Polycystic kidney disease
  • İstanbul Üniversitesi Adresli: Evet

Özet

BackgroundNephrolithiasis is more common in autosomal dominant polycystic kidney disease (ADPKD) than in the normal population. We aimed to investigate the anatomical and metabolic factors that may be associated with nephrolithiasis in patients with ADPKDMethodsIn this cross-sectional study, a total of 180 participants were included. Eighty-five patients with ADPKD [42 patients with nephrolithiasis (PKD N +) and 43 without nephrolithiasis (PKD N -)] were recruited. Forty-seven nephrolithiasis patients without ADPKD (N) and 48 healthy controls (HC) were selected as control groups. 24-h urine collections were measured in all participants. 24-h urine citrate, calcium, urate, oxalate, magnesium and sodium, serum electrolytes, and eGFRs were compared.ResultsTotal kidney volumes were not different between patients with PKD N + and PKD N -. Hypocitraturia was common in all patients with ADPKD (69.4%), and it was not different between PKD N + (76.2%) and PKD N- (62.8%). However, hypocitraturia was statistically higher in PKD N + and PKD N - than in N (38.3%) and HC (12.5%) (p<0.05). 24-h urine calcium, urate, and oxalate levels were similar between PKD N + and PKD N -ConclusionsHypocitraturia was found to be significantly higher in patients with ADPKD than in healthy adults and other kidney stone patients.