Akademik Veri Yönetim Sistemi
Sabiad , cilt.6, sa.2, ss.153-159, 2023 (Hakemli Dergi)
Objective: In this study, our goal was to observe the effect of zoledronic acid histopathologically, which is used without removing the periodontitis agent, on the healing potential of the tissue after the experimental periodontitis formation in an animal model. Material and Method: 30 adult male Sprague-Dawley rats were divided into 2 groups as bisphosphonate users and non-users. At the beginning of the experiment, all rats were put under anesthesia, and 5.0 silk sutures were placed around their right upper first molars. No suture was placed around the left upper first molar teeth. It was waited for 3 weeks after the placement of the sutures. After experimental periodontitis was observed in the animals on the 21st day, 7.5uq/kg zoledronic acid was injected intramuscularly for 6 weeks in the animals in the experimental group. After intramuscular drug administration once a week for 6 weeks, weekly weight monitoring was performed on days 0, 7, 14, 21, 28, and 35 and noted in the experimental group rats. At the end of 6 weeks, the sutures were removed under the anesthesia from the experimental group animals whose last drug injections were completed and the control group animals that were administered 0.9% saline on the same days. A recovery period of two weeks was expected after which all animals were sacrificed. Results: Zoledronic acid was used in the histological evaluation results, and experimental inflammation, necrosis, periodontal space and epithelial proliferation in the group with periodontitis statistically significant p<0.05 was found to be higher. Conclusion: When evaluated clinically, positive effects on wound healing were observed in rats treated with bisphosphonate-derived drugs by treating existing periodontitis prior to drug administration.