Size distribution of circulating cell-free DNA in sera of breast cancer patients in the course of adjuvant chemotherapy

Deligezer, UĞUR; Eralp, Yesim; Akisik, EBRU; Akisik, Elif; Saip, PINAR; Topuz, Erkan; Dalay, Nejat

doi:10.1515/cclm.2008.080

Size distribution of circulating cell-free DNA in sera of breast cancer patients in the course of adjuvant chemotherapy

Deligezer U., Eralp Y., Akisik E. E., Akisik E. Z., Saip P., Topuz E., ...Daha Fazla

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, cilt.46, sa.3, ss.311-317, 2008 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 46 Sayı: 3
Basım Tarihi: 2008
Doi Numarası: 10.1515/cclm.2008.080
Dergi Adı: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.311-317
Anahtar Kelimeler: adjuvant therapy, breast cancer, cell-free DNA, serum, size distribution, GENE PROMOTER HYPERMETHYLATION, REAL-TIME PCR, NUCLEIC-ACIDS, PROSTATE-CANCER, TUMOR DNA, PLASMA, APOPTOSIS, DOXORUBICIN, INTEGRITY, THERAPY
İstanbul Üniversitesi Adresli: Evet

Özet

Background: The integrity of circulating cell-free DNA (cf-DNA) in serum or plasma appears to be of diagnostic and prognostic value in cancer. Here, we investigated the dynamics of serum DNA levels and the size distribution of cf-DNA during adjuvant chemotherapy of patients with breast cancer (n =73).