Size distribution of circulating cell-free DNA in sera of breast cancer patients in the course of adjuvant chemotherapy

Deligezer, UĞUR; Eralp, Yesim; Akisik, EBRU; Akisik, Elif; Saip, PINAR; Topuz, Erkan; Dalay, Nejat

doi:10.1515/cclm.2008.080

Size distribution of circulating cell-free DNA in sera of breast cancer patients in the course of adjuvant chemotherapy

Deligezer U., Eralp Y., Akisik E. E., Akisik E. Z., Saip P., Topuz E., ...More

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, vol.46, no.3, pp.311-317, 2008 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 46 Issue: 3
Publication Date: 2008
Doi Number: 10.1515/cclm.2008.080
Journal Name: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.311-317
Keywords: adjuvant therapy, breast cancer, cell-free DNA, serum, size distribution, GENE PROMOTER HYPERMETHYLATION, REAL-TIME PCR, NUCLEIC-ACIDS, PROSTATE-CANCER, TUMOR DNA, PLASMA, APOPTOSIS, DOXORUBICIN, INTEGRITY, THERAPY
Istanbul University Affiliated: Yes

Abstract

Background: The integrity of circulating cell-free DNA (cf-DNA) in serum or plasma appears to be of diagnostic and prognostic value in cancer. Here, we investigated the dynamics of serum DNA levels and the size distribution of cf-DNA during adjuvant chemotherapy of patients with breast cancer (n =73).