T-cell large granular lymphocytic leukaemia: successful response to 2-deoxycoformycin
NETHERLANDS JOURNAL OF MEDICINE, vol.66, no.2, pp.85-87, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 66 Issue: 2
- Publication Date: 2008
- Journal Name: NETHERLANDS JOURNAL OF MEDICINE
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.85-87
- Istanbul University Affiliated: Yes
Abstract
We report a 25-year-old woman with T-cell large granular lymphocytic leukaemia presenting with severe neutropenia, anaemia and recurrent infections with a chronic disease course. Immunophenotyping showed an expansion of CD3+, TCR gamma delta(+), CD4-, CD5+, CD7+, CD8+, CD57+ large granular lymphocytes. Clonality was demonstrated with T-gamma polymerase chain reaction analysis which revealed clonal rearrangement of the TCR gamma chain gene. Cyclosporine, granulocyte colony-stimulating factor, methothrexate and a combination of cyclophosphamide, vincristine and prednisolone failed to correct the neutropenia and the anaemia. Finally, treatment with 2-deoxycoformycin resulted in both clinical and haemotological complete responses, despite molecular evidence of the persistence of the abnormal T-cell clone.