Gradual Versus Abrupt Reperfusion During Primary Percutaneous Coronary Interventions in ST-Segment-Elevation Myocardial Infarction (GUARD)


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Sezer M., Escaned J., Broyd C. J., Umman B., Bugra Z., Ozcan I., ...Daha Fazla

JOURNAL OF THE AMERICAN HEART ASSOCIATION, cilt.11, sa.10, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 10
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1161/jaha.121.024172
  • Dergi Adı: JOURNAL OF THE AMERICAN HEART ASSOCIATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Anahtar Kelimeler: coronary microvascular resistance, intramyocardial hemorrhage, microvascular injury, myocardial edema, primary PCI, reperfusion injury, ST-segment-elevation myocardial infarction, ZERO-FLOW PRESSURE, MICROVASCULAR OBSTRUCTION, PROGNOSTIC VALUE, NO-REFLOW, SIZE, HEMODYNAMICS, RESTORATION, DYSFUNCTION, IMPROVEMENT, HEMORRHAGE
  • İstanbul Üniversitesi Adresli: Evet

Özet

BACKGROUND: Intramyocardial edema and hemorrhage are key pathological mechanisms in the development of reperfusion-related microvascular damage in ST-segment-elevation myocardial infarction. These processes may be facilitated by abrupt restoration of intracoronary pressure and flow triggered by primary percutaneous coronary intervention. We investigated whether pressure-controlled reperfusion via gradual reopening of the infarct-related artery may limit microvascular injury in patients undergoing primary percutaneous coronary intervention.