JOURNAL OF THE AMERICAN HEART ASSOCIATION, vol.11, no.10, 2022 (Journal Indexed in SCI)
Article / Article
JOURNAL OF THE AMERICAN HEART ASSOCIATION
Science Citation Index Expanded, Scopus, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
coronary microvascular resistance, intramyocardial hemorrhage, microvascular injury, myocardial edema, primary PCI, reperfusion injury, ST-segment-elevation myocardial infarction, ZERO-FLOW PRESSURE, MICROVASCULAR OBSTRUCTION, PROGNOSTIC VALUE, NO-REFLOW, SIZE, HEMODYNAMICS, RESTORATION, DYSFUNCTION, IMPROVEMENT, HEMORRHAGE
BACKGROUND: Intramyocardial edema and hemorrhage are key pathological mechanisms in the development of reperfusion-related microvascular damage in ST-segment-elevation myocardial infarction. These processes may be facilitated by abrupt restoration of intracoronary pressure and flow triggered by primary percutaneous coronary intervention. We investigated whether pressure-controlled reperfusion via gradual reopening of the infarct-related artery may limit microvascular injury in patients undergoing primary percutaneous coronary intervention.