Perception and management of cancer predisposition in pediatric cancer centers: A European-wide questionnaire-based survey

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Lazic J., Haas O. A., Özbek U., Ripperger T., Byrjalsen A., Te Kronnie G., ...More

Pediatric Blood and Cancer, vol.70, no.5, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 5
  • Publication Date: 2023
  • Doi Number: 10.1002/pbc.30229
  • Journal Name: Pediatric Blood and Cancer
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: cancer genetics, germ cell tumor, pediatric hematology/oncology
  • Istanbul University Affiliated: Yes


The European Union-funded COST Action (LEukaemia GENe Discovery by data sharing, mining, and collaboration) LEGEND was an international and multidisciplinary collaboration between clinicians and researchers that covered a range of aspects of genetic predisposition in childhood leukemia. Within this framework, we explored the perception and handling of genetic predisposition in the daily practice of European treatment centers. Herein, we present the results of our questionnaire-based survey. We found that the overall awareness is quite high, and respondents remarked that identification and treatment of the most common predisposition syndromes were present. Nevertheless, high demand for continuous education and routinely updated resources remains.