Oxidative damage parameters in renal tissues of aged and young rats based on gender

Uzun D., Korkmaz G. G., Sitar M. E., Cebe T., Yanar K., Cakatay U., ...Daha Fazla

CLINICAL INTERVENTIONS IN AGING, cilt.8, ss.809-815, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8
  • Basım Tarihi: 2013
  • Doi Numarası: 10.2147/cia.s46188
  • Dergi Adı: CLINICAL INTERVENTIONS IN AGING
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.809-815
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: Aging is characterized by a gradual functional decrease of all systems including the kidneys. Growing evidence links altered lipid protein redox-homeostasis with renal dysfunction. The effect of sexual dimorphism on the lipid protein redox-homeostasis mechanisms in the aging kidney is obscure. In the current study, we aimed to investigate redox homeostasis as it related to sexual dimorphism on protein oxidation and lipid peroxidation parameters, as protein carbonyl (PCO), total thiol (T-SH), advanced oxidation protein products (AOPP), malondialdehyde, glutathione (GSH), and superoxide dismutase (SOD) activity, as potential aging biomarkers, which may contribute to an analysis of the free radical theory of aging.