Determination of aminoglutethimide enantiomers as dansyl derivative in human plasma by HPLC with fluorescence detection

Aboul-Enein H., Ozkirimli S., Apak T.

ARCHIV DER PHARMAZIE, vol.332, no.4, pp.145-147, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 332 Issue: 4
  • Publication Date: 1999
  • Journal Name: ARCHIV DER PHARMAZIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.145-147
  • Istanbul University Affiliated: No

Abstract

Determination of aminoglutethimide enantiomers as a dansyl derivative in plasma by HPLC has been achieved using cellulose tris(3,5-dimethylphenyl carbamate) chiral stationary phase known as Chiralcel OD, and a mobile phase consisted of ethanol-cyclohexane-methanol (95:5:2 nu/nu/nu). The limit of detection for each enantiomer of aminoglutethimide using fluorescence detector was 20 ng ml(-1).