Determination of aminoglutethimide enantiomers as dansyl derivative in human plasma by HPLC with fluorescence detection


Aboul-Enein H., Ozkirimli S., Apak T.

ARCHIV DER PHARMAZIE, cilt.332, sa.4, ss.145-147, 1999 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 332 Konu: 4
  • Basım Tarihi: 1999
  • Dergi Adı: ARCHIV DER PHARMAZIE
  • Sayfa Sayıları: ss.145-147

Özet

Determination of aminoglutethimide enantiomers as a dansyl derivative in plasma by HPLC has been achieved using cellulose tris(3,5-dimethylphenyl carbamate) chiral stationary phase known as Chiralcel OD, and a mobile phase consisted of ethanol-cyclohexane-methanol (95:5:2 nu/nu/nu). The limit of detection for each enantiomer of aminoglutethimide using fluorescence detector was 20 ng ml(-1).