Fingolimod impairs inactivated vaccine (CoronaVac)-induced antibody response to SARS-CoV-2 spike protein in persons with multiple sclerosis.

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Türkoğlu R., Baliç N., Kızılay T., Erol R., Akbayır E., Yılmaz V., ...More

Multiple sclerosis and related disorders, vol.58, pp.103524, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Letter
  • Volume: 58
  • Publication Date: 2022
  • Doi Number: 10.1016/j.msard.2022.103524
  • Journal Name: Multiple sclerosis and related disorders
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.103524
  • Keywords: COVID-19, SARS-COV-2, Vaccination, CoronaVac, Multiple sclerosis, Fingolimod
  • Istanbul University Affiliated: Yes

Abstract

Background: : The impact of disease-modifying treatments on humoral response induced by inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines is understudied. Methods: : We recruited 34 persons with multiple sclerosis (MS) under fingolimod treatment and 25 healthy individuals. Anti-SARS-CoV-2 spike IgG indices were measured by ELISA in sera of participants after CoronaVac vaccinations. Results: : Persons with MS displayed significantly lower antibody levels and seropositivity prevalence. Persons with MS with longer fingolimod treatment durations displayed lower anti-SARS-CoV-2 indices. Conclusion: : Our results support previous findings regarding humoral response impairing effect of fingolimod after vaccinations. Patients under fingolimod treatment may require closer monitoring for COVID-19.