INVESTIGATION OF THE ANTIBIOTIC RESISTANCE PROFILE OF KLEBSIELLA PNEUMONIAE ISOLATES ISOLATED FROM DIFFERENT CLINICAL SPECIMENS: ONE-YEAR DATA DURING THE COVID-19 PANDEMIC PROCESS FARKLI KLİNİK ÖRNEKLERDEN İZOLE EDİLMİŞ KLEBSIELLA PNEUMONIAE İZOLATLARININ ANTİBİYOTİK DİRENÇ PROFİLİNİN İNCELENMESİ: COVID-19 PANDEMİSİ SÜRECİNDEKİ BİR YILLIK VERİLER


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Doğanay D., Aydin M., Avşar İ. S.

Ankara Universitesi Eczacilik Fakultesi Dergisi, vol.47, no.1, pp.185-195, 2023 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.33483/jfpau.1181432
  • Journal Name: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Journal Indexes: Scopus, Central & Eastern European Academic Source (CEEAS), EMBASE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.185-195
  • Keywords: Antimicrobial resistance, COVID-19, ESBL, Klebsiella pneumoniae, nosocomial infection
  • Istanbul University Affiliated: Yes

Abstract

© 2023 University of Ankara. All rights reserved.Objective: In recent years, the rapid spread of resistance caused by the production of extended-spectrum beta-lactamase (ESBL) among bacteria has increased the importance of K. pneumoniae bacteria. Regular monitoring of antibiotic resistance rates of bacteria is very important for the treatment of infections and new treatment methods that can be developed. In the study, it was aimed to determine the antibiotic resistance profiles and ESBL positivity rates of K. pneumoniae isolated from patients who applied to Biruni University Hospital between March 2020 and March 2021, covering the COVID-19 Pandemic. Material and Method: In the study, antibiogram test results and ESBL presences of K. pneumoniae bacteria isolated from samples sent from different outpatient clinics and services were evaluated retrospectively. GraphPad InStat V. 3.05 was used for statistical analysis. Result and Discussion: In the study, 423 K. pneumoniae bacteria were isolated from different clinical samples. Of the isolates, 161 (38%) were obtained from the endotracheal aspirate (ETA) sample, and 349 (82.5%) were obtained from the intensive care clinic. In addition, 358 (84.63%) of the isolates were ESBL positive and 65 (15.36%) ESBL negative. It was observed that the majority of the isolates obtained were resistant to ampicillin, and almost all of the ESBL positive isolates were resistant to ceftazidime. Both the studies and the results of the study show that the number of K. pneumoniae strains showing multiple antibiotic resistance has increased over time and this increase continues exponentially.