Growth Hormone/Insulin-Like Growth Factor-1 Axis as Related to Body Mass Index in Patients with Idiopathic Short Stature
JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.5, sa.1, ss.13-19, 2013 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 5 Sayı: 1
- Basım Tarihi: 2013
- Doi Numarası: 10.4274/jcrpe.901
- Dergi Adı: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.13-19
- Anahtar Kelimeler: Idiopathic short stature, insulin-like growth factor 1 (IGF-1), body mass index, IGF-1 receptor, IGF-binding protein 3 (IGFBP)-3, IGF-1 generation test, IGF-I, TURKISH CHILDREN, HORMONE INSENSITIVITY, PREPUBERTAL CHILDREN, PUBERTAL CHANGES, SERUM-LEVELS, GH, REFERENCES, RECEPTOR, OBESITY
- İstanbul Üniversitesi Adresli: Evet
Özet
Objective: Idiopathic short stature (ISS) is a heterogeneous disorder. An impairment of growth hormone (GH)/insulin-like growth factor 1 (IGF-1)/IGF-1 receptor (IGF-1 R) axis is postulated. To evaluate the somatotropic axis in relation to body mass index (BMI), serum IGF-1, IGF-binding protein-3 (IGFBP-3) and the expression of IGF-1 R genes in patients with ISS.