Growth Hormone/Insulin-Like Growth Factor-1 Axis as Related to Body Mass Index in Patients with Idiopathic Short Stature

Cengiz P., Bas F., Atalar F., Ucar A., Darendeliler F., Akan G., ...More

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, vol.5, no.1, pp.13-19, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.4274/jcrpe.901
  • Journal Name: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.13-19
  • Keywords: Idiopathic short stature, insulin-like growth factor 1 (IGF-1), body mass index, IGF-1 receptor, IGF-binding protein 3 (IGFBP)-3, IGF-1 generation test, IGF-I, TURKISH CHILDREN, HORMONE INSENSITIVITY, PREPUBERTAL CHILDREN, PUBERTAL CHANGES, SERUM-LEVELS, GH, REFERENCES, RECEPTOR, OBESITY
  • Istanbul University Affiliated: Yes

Abstract

Objective: Idiopathic short stature (ISS) is a heterogeneous disorder. An impairment of growth hormone (GH)/insulin-like growth factor 1 (IGF-1)/IGF-1 receptor (IGF-1 R) axis is postulated. To evaluate the somatotropic axis in relation to body mass index (BMI), serum IGF-1, IGF-binding protein-3 (IGFBP-3) and the expression of IGF-1 R genes in patients with ISS.