The miRNA 196a2 rs11614913 variant has prognostic impact on Turkish patients with multiple myeloma.


Kirik M. P., Pehlivan M., Nursal A. F., Oyaci Y., Pehlivan S., Serin I.

BMC research notes, vol.13, pp.545, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13
  • Publication Date: 2020
  • Doi Number: 10.1186/s13104-020-05392-9
  • Journal Name: BMC research notes
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, Directory of Open Access Journals
  • Page Numbers: pp.545
  • Keywords: Multiple myeloma, miR-196a2, Autologous stem cell transplantation, Prognosis, GENETIC VARIANT, BREAST-CANCER, LUNG-CANCER, MICRORNA-196A2, POLYMORPHISM, RISK, SUSCEPTIBILITY
  • Istanbul University Affiliated: Yes

Abstract

Objective Multiple myeloma (MM) arises from malignant plasma cells as a single clone in the bone marrow. Accumulating evidences have reported that there is an association between miR-196a2 (rs11614913) variant and various cancers while there were unverified and inconsistent results in MM. The goal of this study is to investigate the impact of the miR-196a2 variant on clinical findings and susceptibility in MM. Two hundred MM patients (156 patients under transplantation of autologous stem cell) and 200 healthy controls included in this study. Results The statistical analysis showed no significant relationship for allele and frequencies of miR-196a2 genotype between patients and controls (p > 0.05). Log-rank test showed that gender has highly significant impact on both OS and PFS (p = 0.027, p = 0.045). In the univariate analysis, TT genotype (p = 0.022), and CT/TT (p = 0.008) had better OS. In the multivariate analysis, CC/CT-TT were associated with positively OS (p = 0.041). Currently, the most valuable prognostic markers in MM that has clinical implication are genetic abnormalities. It can be concluded from the results that miR-1962a variant is effective in prognosis of the MM. It is believed that these findings will help us understand the molecular basis of disease.