Silencing of Wwox Increases Nuclear Import of Dvl proteins in Head and Neck Cancer

Celebi A., Orhan C., Seyhan B., Buyru N.

JOURNAL OF CANCER, vol.11, no.14, pp.4030-4036, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 14
  • Publication Date: 2020
  • Doi Number: 10.7150/jca.40840
  • Journal Name: JOURNAL OF CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Directory of Open Access Journals
  • Page Numbers: pp.4030-4036
  • Istanbul University Affiliated: Yes

Abstract

Background: Wnt signaling pathway is associated with a variety of human cancers, including HNSCC. Wnt proteins control cellular events such as proliferation, fate specification, polarity, and migration by transducing signals to the nucleus through several cytoplasmic relay proteins. Although activation of the Wnt/beta-catenin pathway is a frequent event in various cancers, there is limited knowledge on the contribution of this signaling mechanism in HNSCC. The Wwox tumor suppressor protein participates in the regulation of Wnt signaling by interacting with Dvl proteins.