TERT Expression in Pituitary Adenomas


CAN N., ÇELİK M., BÜLBÜL B. Y., SÜT N., ÖZYILMAZ F., AYTÜRK SALT S., ...More

TURKISH JOURNAL OF PATHOLOGY, vol.33, no.2, pp.103-111, 2017 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 2
  • Publication Date: 2017
  • Doi Number: 10.5146/tjpath.2016.01387
  • Journal Name: TURKISH JOURNAL OF PATHOLOGY
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.103-111
  • Keywords: Pituitary adenomas, Telomerase reverse transcriptase, Clinicopathological features, TELOMERASE ACTIVITY, TUMORS, PROLIFERATION, MUTATIONS, LENGTH
  • Istanbul University Affiliated: No

Abstract

Objective: Although pituitary adenomas have benign histomorphological features, some of them may present in an aggressive manner. To predict the behaviour of these tumours, telomerase reverse transcriptase (TERT) activity in pituitary adenomas has been the subject of a few studies with contradictory results. This study aims to investigate whether immunohistochemical expression of TERT differs in neoplastic and nonneoplastic pituitary tissues and aims to investigate whether TERT expression is related to clinicopathological features of pituitary adenomas.