TERT Expression in Pituitary Adenomas

CAN N., ÇELİK M., BÜLBÜL B. Y., SÜT N., ÖZYILMAZ F., AYTÜRK SALT S., ...Daha Fazla

TURKISH JOURNAL OF PATHOLOGY, cilt.33, sa.2, ss.103-111, 2017 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5146/tjpath.2016.01387
  • Dergi Adı: TURKISH JOURNAL OF PATHOLOGY
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.103-111
  • Anahtar Kelimeler: Pituitary adenomas, Telomerase reverse transcriptase, Clinicopathological features, TELOMERASE ACTIVITY, TUMORS, PROLIFERATION, MUTATIONS, LENGTH
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Objective: Although pituitary adenomas have benign histomorphological features, some of them may present in an aggressive manner. To predict the behaviour of these tumours, telomerase reverse transcriptase (TERT) activity in pituitary adenomas has been the subject of a few studies with contradictory results. This study aims to investigate whether immunohistochemical expression of TERT differs in neoplastic and nonneoplastic pituitary tissues and aims to investigate whether TERT expression is related to clinicopathological features of pituitary adenomas.