ACTA FARMACEUTICA BONAERENSE, vol.42, no.1, pp.1-8, 2023 (SCI-Expanded)
Formulating poorly water-soluble medications is one of the most crucial challenges encountered
in the pharmaceutical industry. Due to this obstacle, the model drug chosen for this research was Nimesulide.
The primary goal of this research was to obtain information on the drug’s physical and chemical properties,
either alone or in combination with excipients, in order design a formulation and create a stable and bioavailable dosage form. Formulations were designed using Flowlac®100 and Avicel®102 as fillers, Kollidon®30 as
a binder, Magnesium stearate as a lubricant, and variable concentrations of Kollidon®CL and Primojel as
superdisintegrants. The tableting process was conducted using using a compaction simulator. The Quality by
Design (QbD) approach allows formulators to enhance product development with built-in product quality.
In this study, to understand the relationship between excipients and compaction force differences on tablet
properties, the QbD approach was applied by using a compaction simulator.