New nickel(II) complexes containing N2O2 donor thiosemicarbazones: Synthesis, characterization and antioxidant properties

Eglence-Bakir S.

JOURNAL OF MOLECULAR STRUCTURE, vol.1246, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 1246
  • Publication Date: 2021
  • Doi Number: 10.1016/j.molstruc.2021.131121
  • Journal Name: JOURNAL OF MOLECULAR STRUCTURE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, INSPEC
  • Keywords: Thiosemicarbazone, Nickel (II) complex, X-ray diffraction, Antioxidant capacity, Radical scavenging, SUBSTITUTED THIOSEMICARBAZONES, DIOXOMOLYBDENUM(VI) COMPLEXES, LIGANDS SYNTHESIS, INHIBITION, COPPER(II), FLAVONOIDS, IRON(III), CATALASE
  • Istanbul University Affiliated: Yes

Abstract

Six nickel(II) complexes containing N2O2 chelating thiosemicarbazones were synthesized using N1-3/4/5-methoxysalicylidene-S-methyl/propyl thiosemicarbazones and 4-benzyloxy-salicylaldehyde in the pres-ence of Ni(II) ion by template reaction. The structures of synthesized compounds were character-ized by elemental analysis, UV-Vis, IR and 1H-NMR spectroscopies. The structures of two complexes, N1-4-methoxysalicylidene-N4-4-benzyloxysalicylidene-S-methylthiosemicarbazidato nickel(II) ( 3 ) and N 1 -5-methoxysalicylidene-N4-4-benzyloxysalicylidene-S-propylthiosemicarbazidato nickel(II) ( 6 ), were deter-mined by X-ray single-crystal diffraction method. The total antioxidant capacities of thiosemicarbazones and nickel(II) complexes were evaluated by using cupric reducing antioxidant capacity (CUPRAC) method. The obtained trolox equivalent antioxidant capacity (TEAC) values of the thiosemicarbazones were higher than nickel(II) complexes. 5-methoxy substitute derivatives ( L 5 , L 6 ) exhibited the highest activity in thiosemicarbazone compounds. The hydroxyl radical, DPPH radical and ABTS radical scavenging ability of the compounds were also evaluated. (c) 2021 Elsevier B.V. All rights reserved.