Influence of conversion from calcineurin inhibitors to everolimus on fibrosis, inflammation, tubular damage and vascular function in renal transplant patients

Alpay, Nadir; Ozkok, Abdullah; Caliskan, Yasar; Akagun, Tülin; Cinar, SUZAN; Deniz, GÜNNUR; Sariyar, Muzaffer; Yildiz, ALAATTİN

doi:10.1007/s10157-014-0939-4

Influence of conversion from calcineurin inhibitors to everolimus on fibrosis, inflammation, tubular damage and vascular function in renal transplant patients

Alpay N., Ozkok A., Caliskan Y., Akagun T., Cinar S., Deniz G., ...More

CLINICAL AND EXPERIMENTAL NEPHROLOGY, vol.18, no.6, pp.961-967, 2014 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 18 Issue: 6
Publication Date: 2014
Doi Number: 10.1007/s10157-014-0939-4
Journal Name: CLINICAL AND EXPERIMENTAL NEPHROLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.961-967
Istanbul University Affiliated: Yes

Abstract

Conversion from calcineurin inhibitor (CNI) to mTOR inhibitors may reduce and even halt the progression of chronic allograft dysfunction (CAD) which is the most important cause of renal allograft loss. We aimed to investigate the effects of conversion from CNI to everolimus on parameters of fibrosis, inflammation, glomerulotubular damage and vascular functions in renal transplant recipients.