Effects of streptozotocin-induced diabetes and pentylenetetrazol-induced seizure on brain cortex Ca(2+)ATPase activity in rats

Oner P., Kocak H., Oztas B.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.103, ss.33-40, 2000 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 103
  • Basım Tarihi: 2000
  • Doi Numarası: 10.3109/00207450009003250
  • Sayfa Sayıları: ss.33-40


The aim of the present study was to obtain information about the effects of pentylenetetrazol-induced status epileptious (SE) and streptozotocin-induced diabetes on brain cortex Ca2+ ATPase activity. Treatment with pentylenetetrazol (PTZ) and streptozotocin (STZ) to rats resulted in significant decrease in brain cortex Ca2+ ATPase activity as compared with controls. However, PTZ-treated diabetic rats had a slight but non-significant decrease in enzyme activity. Treatment with PTZ caused a more pronounced effect in inhibiting enzyme activity than that of treatment with STZ. Our results concluded that reduced brain cortex Ca2+ ATPase activity following PTZ and STZ treatments to rats, may be an initial biochemical lesion which triggers a sequence of events which may culminate in cell death.